Detailed view for Smp_158310

Basic information

TDR Targets ID: 294476
Schistosoma mansoni, multiple ankyrin repeats single kh domain protein
Source Database / ID:  GeneDB

pI: 6.6225 | Length (AA): 2797 | MW (Da): 299005 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00013   KH domain
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 124 2rfm (A) 45 154 28.00 0.000000098 1 0.414173 -0.71
11 150 5aqb (A) 41 160 33.00 0 1 0.321754 -0.1
11 133 2f8y (A) 1956 2094 23.00 0.00000013 0.99 0.231676 -0.27
14 150 5d66 (A) 71 226 34.00 0.00000046 1 0.313681 -0.13
29 146 1wdy (A) 21 136 23.00 0.0000000028 1 0.420888 -0.67
50 554 5y4d (A) 2185 2682 32.00 0 1 0.600851 -0.32
94 223 4lg6 (A) 175 303 35.00 0.000000000014 1 0.629778 -1.45
124 485 6f5e (A) 11 320 43.00 0 1 0.422724 0.45
206 1237 4rlv (A) 2036 2813 34.00 0 1 0.327267 1.2
364 471 3c5r (A) 0 531 41.00 0.0000000014 1 0.656913 -1.2
370 490 1n0r (A) 4 124 54.00 0 1 0.807561 -1.36
405 553 4gpm (A) 8 155 41.00 0 1 0.687571 -1.36
506 1267 4rlv (A) 2102 2804 19.00 0 1 0.339135 0.95
1210 1291 5h2a (A) 90 172 26.00 0.12 0.75 0.287017 -0.41
1211 1254 1sw6 (A) 463 507 34.00 0.15 0.47 0.346431 0.28
1261 1330 3v6i (B) 24 105 43.00 0.21 0.03 0.422727 -1.43
1616 1686 3vke (A) 14 83 33.00 0.25 0.98 0.525684 -1.54
1617 1685 2hh2 (A) 12 80 25.00 0.021 0.88 0.422369 -1.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130413)

Species Accession Gene Product
Brugia malayi Bm1_21440   KH domain containing protein
Caenorhabditis elegans CELE_R11A8.7a   Protein R11A8.7, isoform H
Caenorhabditis elegans CELE_R11A8.7   Protein R11A8.7, isoform F
Drosophila melanogaster Dmel_CG33106   multiple ankyrin repeats single KH domain
Echinococcus granulosus EgrG_000508600   Ankyrin repeat domain containing protein
Echinococcus granulosus EgrG_000134900   ankyrin domain repeat containing protein
Echinococcus granulosus EgrG_000509400   Ankyrin
Echinococcus granulosus EgrG_000508200   Ankyrin repeat domain containing protein
Echinococcus granulosus EgrG_002054500   ankyrin repeat domain containing protein 17
Echinococcus granulosus EgrG_000508800   Ankyrin repeat domain containing protein
Echinococcus granulosus EgrG_000710600   ankyrin domain repeat containing protein
Echinococcus granulosus EgrG_000508100   ankyrin repeat domain protein 17
Echinococcus granulosus EgrG_000134200   ankyrin domain repeat containing protein
Echinococcus granulosus EgrG_000494700   ankyrin repeat and KH domain containing protein
Echinococcus granulosus EgrG_000508000   ankyrin domain repeat containing protein
Echinococcus granulosus EgrG_002064400   Ank_2 domain containing protein
Echinococcus multilocularis EmuJ_000509400   Ankyrin
Echinococcus multilocularis EmuJ_000508000   ankyrin domain repeat containing protein
Echinococcus multilocularis EmuJ_000508200   Ankyrin repeat domain containing protein
Echinococcus multilocularis EmuJ_000134200   ankyrin domain repeat containing protein
Echinococcus multilocularis EmuJ_000508600   Ankyrin repeat domain containing protein
Echinococcus multilocularis EmuJ_000710600   ankyrin domain repeat containing protein
Echinococcus multilocularis EmuJ_000134900   ankyrin domain repeat containing protein
Echinococcus multilocularis EmuJ_000508800   Ankyrin repeat domain containing protein
Echinococcus multilocularis EmuJ_000508100   ankyrin repeat domain protein 17
Echinococcus multilocularis EmuJ_001201800   ankyrin domain repeat containing protein
Echinococcus multilocularis EmuJ_000494700   ankyrin repeat domain protein 17
Homo sapiens ENSG00000254996   ANKHD1-EIF4EBP3 readthrough
Homo sapiens ENSG00000132466   ankyrin repeat domain 17
Homo sapiens ENSG00000131503   ankyrin repeat and KH domain containing 1
Loa Loa (eye worm) LOAG_07592   ankyrin repeat-containing protein
Loa Loa (eye worm) LOAG_07591   hypothetical protein
Loa Loa (eye worm) LOAG_07543   hypothetical protein
Mus musculus ENSMUSG00000055204   ankyrin repeat domain 17
Mus musculus ENSMUSG00000024483   ankyrin repeat and KH domain containing 1
Onchocerca volvulus OVOC5622   Putative multiple ankyrin repeats single kh domain protein
Schistosoma japonicum Sjp_0119140   Ankyrin repeat and KH domain-containing protein 1, putative
Schistosoma japonicum Sjp_0116100   Ankyrin repeat domain-containing protein 17, putative
Schistosoma japonicum Sjp_0075620   Ankyrin repeat and KH domain-containing protein mask, putative
Schistosoma japonicum Sjp_0124710   expressed protein
Schistosoma japonicum Sjp_0120640   expressed protein
Schistosoma japonicum Sjp_0130180   Ankyrin repeat and KH domain-containing protein 1, putative
Schistosoma mansoni Smp_158310   multiple ankyrin repeats single kh domain protein
Schmidtea mediterranea mk4.004233.00   Putative multiple ankyrin repeats single kh domain protein
Schmidtea mediterranea mk4.006391.01  
Schmidtea mediterranea mk4.000560.10  
Schmidtea mediterranea mk4.004233.01   Putative multiple ankyrin repeats single kh domain protein

Essentiality

Smp_158310 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R11A8.7 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_158310 (Schistosoma mansoni), multiple ankyrin repeats single kh domain protein
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